Hope raises its reckless head above the Covid parapet

Britain has approved two Covid vaccines and hope is raising its reckless head above the parapet. So what does the government do? It hustles us back to its comfort zone, which is chaos. 

 

Vaccine dosage and the mathematics of gambling

A few days ago, someone in or near the government realized that if people need two doses of vaccine, that means the country needs (pay attention here, because this is complicated) two doses for every person who gets vaccinated. Not to mention enough people and places to vaccinate them twice. And we need to vaccinate almost everyone, which is, in technical terms, a shitload of people.

But, look! If we divide two by two, we get one. 

Who knew?

So let’s give everyone a single dose and tell them to wait a while for the second. That way we’ll get the vaccine to more people. 

This is very clever. 

Irrelevant photo: Daffodils. I saw the first ones in bloom last week. Not these–these are from last year–but you get the basic idea.

Doctors made loud and unhappy sounds. People who already got one injection were given appointments for the second, they said. Who’s going to unschedule them? We (this is the doctors speaking, remember, in unison) and our staff are already at the breaking point and don’t have time to unschedule. What do you want us to do with these people when they show up?

And by the way, does anyone have access to a study indicating that postponing the second vaccination is safe?

Oh, that, the government said. We’ve done some modeling. Short term, it’ll be fine. This will save more lives than the original plan.

The government didn’t hear that noise about appointments. Appointments are Someone Else’s Problem, and as that great philosopher and scientist Douglas Adams pointed out, that means it falls into an SEP field, where becomes invisible.

So let’s stick with the question of studies showing that this is a good idea. Pfizer, the maker of one of the vaccines, said, “There are no data to demonstrate that protection after the first dose is sustained after 21 days.” And the US’s Dr. Fauci said something along the lines of, Do what you like over there, be we’re not crazy enough to try it here. 

I’m not putting that in quotes because it’s not a quote. He was considerably more diplomatic.

Scientists–at least in Britain–seem to be split. 

And the public? By now, most of us will take any gamble that’s offered. Remember that business about hope’s reckless head? It’s a beautiful sight. We’re in love.

How much protection will a single shot give us for how long? Who the fuck knows? Some. For a while. That’s better than none for eternity. 

They’re talking about delivering the second dose three months after the first, but I don’t recommend betting anything you’re attached to on it working out that way.

 

The mix-and-match experiment

But why create chaos in one way when the world offers us so many possibilities? 

As far as I can reconstruct this–and it’s not that far, so don’t put too much weight on the sequence of events here–Public Health England published some advice saying it was reasonable to give people one dose of one vaccine and one of another. If necessary.

Why would it be necessary? If, say, the first vaccine isn’t available when the second dose is due. (Whenever, that is, it does turn out to be due.) Or if the person doesn’t know which vaccine they got for a first does and their paperwork’s disappeared into an SEP field. 

“This option is preferred if the individual is likely to be at immediate high risk or is considered unlikely to attend again,” Public Health England wrote.

Cue criticism from assorted experts. 

The New York Times quoted virologist Prof John Moore, who said, “There are no data on this idea whatsoever,” and added that British officials “seem to have abandoned science completely now and are just trying to guess their way out of a mess.”

Which does sound familiar.

Public Health England shot back that they only meant that it would be okay in a crisis. They weren’t recommending it. 

A study of mixed dosing is underway. It might even be better that way. Who the hell knows?

 

The great vaccine roll-out

What, then, stands in the way of getting the vaccine to as many people as possible as quickly as possible? Among other things, a shortage of people capable of sticking needles into other people safely. So of course the government as made it as difficult as possible to recruit people.

A working dentist thought he’d pitch in, since he’s experienced at giving injections. 

Explaining the documentation he was asked for, he said, “Some of the things are really quite sensible, like resuscitation, and recognising and managing anaphylaxis, but then you get things like preventing radicalisation, level 1 certificate required, [or] safeguarding children level 2.

“Children aren’t a priority for vaccination, [so] I really don’t think we’re going to be seeing children.

“I must admit, I gave up at the second hurdle, because I’m very busy as a dentist and I do get home quite tired at night. I thought ‘good grief, If I have to go through all this, I’m not [doing it].’ “

Would that they took this much care when they were handing out contracts for Covid testing and tracing.

 

Are schools open or closed?

Yes. But for a while there we weren’t sure which.

A few days before they were due to open, head teachers–if you’re American, that means principals–weren’t sure which they were preparing for. But as I type this on Sunday the prime minister has finally announced that primary schools will open. Except in London and southeastern England, where they’ll stay closed for two weeks  because of the new Covid variant, which is believed to be more infectious. Even though the variant sneaked out of London and the southeast before the holidays and enjoyed a lovely Christmas and New Year’s break in other parts of the country. 

But why not wait till it gets a good hold elsewhere and react then?

Meanwhile, teachers unions are calling for primary schools to stay closed and head teachers have started legal action, hoping they’ll force the government to cough up the data behind its decision to reopen the schools. It’s a good idea, but the government’s beyond the reach of public embarrassment. 

In the meantime, secondary schools are due to reopen on a staggered basis, which is easy since we’re all staggered by now. Universities will open late and their students–some of them–are on rent strike. And Covid testing of students will be carried out by extras from the Dr. Who New Year’s Day special.

Do we know how to throw a party over here or what?

Covid, kids, and rumors

In spite of rumors to the contrary, the new variant doesn’t seem to be hitting children any harder than the old one. A nurse told the BBC that children’s wards were filling up with Covid cases, and the story spread. Hospitals and pediatricians report that they’re not.

Breathe. We have enough trouble without borrowing any.

The vulnerabilities of younger people: It’s the pandemic update from Britain

England’s world-beating Covid test and trace system has people beating their heads against the wall. Anyone can mistake a wall for the world. It’s natural enough. Even in pandemic hot spots, symptomatic people are being turned away. The government’s labs had a backlog of 185,000 tests that were sent abroad over the weekend. But if test samples sit around too long, they’re useless. So, um, yeah. I’m not sure how that’s going to work. But let’s not be silly and hold out for competence.

English schools are warning that they’ll grind to a halt if students and staff can’t get tested, because people who might test negative will have to isolate.

Wales says it’s going to process its own tests. Scotland accused England of trying to limit its access to tests. Northern Ireland doesn’t seem to be taking part in the conversation, and nobody ever listens to Cornwall.  

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Screamingly irrelevant flowers. Whatsit flowers–probably osteospermum. In bloom. In our yard. They’re wonderful–the slugs don’t eat them.

Meanwhile, Doug Jaquier sent me a bit of wisdom from a Facebook site called Puns, One Liners & Clever Wordplay

“Due to the success of Covid testing the Government has taken over pregnancy testing too. The waiting list is currently 10 months.”

The capitalization is not mine. Neither, sadly, is the inventive mind that thought of that. If they’d waited another lifetime, I would’ve come up with it. I just know I would’ve.

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China has announced that it may have a vaccine ready for use by the public in November or December. It’s currently in phase 3 trials–the ones where they test it on a large number of people to see if it’s both safe and effective.

Britain’s Oxford vaccine phase 3 trials were interrupted when one of the test subjects got sick. They’ve resumed now. Presumably her illness was unrelated. Not that anyone’s actually said that. Confidentiality and discretion absolutely ruin a good bit of gossip. 

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An advisor to the British government said that details of the new rules limiting how many people can gather in what circumstances are irrational–you can get a larger group of people together for a sports event but a family of five can’t have two grandparents visit them at home. 

“It is on the other hand very simple,” he said.

And it is simple until you try to sort through the who, what, when, where, and how.

In case you were worried, you can gather in groups of up to thirty to shoot grouse. So don’t feel too bad about the grandparents. At least no one (that we know of) is hunting them.

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A lot of Britain’s recent Covid cases are among younger people, so let’s talk about the people who it’s hitting like a sledgehammer. The reason I want to focus on them is that we have the illusion that Covid’s only a danger to people over sixty. Or seventy. Or eighty. Younger people are immune. 

Okay, most of us have that illusion. You probably know better, but the rest of us can be pretty dumb sometimes.

At Mount Sinai Health System, in New York, doctors treated five Covid stroke patients in two weeks, all under fifty. Normally they’d see one every three weeks. Four of them were relatively healthy beforehand. Two were in their thirties and had no risk factors. 

That’s a lot of numbers in one paragraph. Five in two weeks instead of one every three. Hold onto that. It’s not a huge number, but it reminds us that the danger to younger people is real. If you have to draw a card out of the Covid deck, you have no way to know what card it’ll be. 

Dr. Adam Dmytriw, a University of Toronto radiologist, says, “We’re seeing a startling number of young people who had a minor cough, or no recollection of viral symptoms at all . . . and they have a sudden stroke.” 

How many is a startling number? Enough to startle a doctor. That’s the best I can do, because the article didn’t say. Some of them had underlying medical conditions, but none had risks that should have increased their chance of having a stroke. For some, the stroke was the first sign that they had the coronavirus because they had the mild cases we all expect them to have.

In the U.S., the number of hospitalizations among 18- to 29-year-olds quadrupled in just a couple months. From the week ending April 18 to the one ending June 27, it went from just under 9 for every 100,000 to roughly 35 per 100,000. It’s not a huge number, but it’s a big jump for a short stretch of time.

One study, again of Americans, says a third of all younger people have at least one risk factor for severe Covid. 

Other younger people end up with some version of post-Covid syndrome, which can include exhaustion, chest pains, migraines, breathlessness, dizziness. About 600,000 people (I think that’s in Britain, and it seems to include all ages, but don’t take my word for that) have some version of post-Covid syndrome as measured by the app Covid Tracker. Around 12% of them have had it for more than a month and one in two hundred for more than 90 days.

Something close to 100% of British publications (at least the ones I read) don’t bother to translate their statistics into comparable categories. I think that would be .5%, but I’m not going to crawl too far out on that limb.

The initial belief that Covid risk rises with age still seems to hold true, but even so the evidence is increasing that younger people aren’t immune. A retrospective Chinese study of Covid in children counts 2,143 cases. More than 90% of them were mild or moderate, but 6% of pediatric cases were severe and even critical, compared to 19% of adult cases. 

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Isn’t it just fun to spend time with me? Doom, gloom, and after that I’m out of relevant rhymes.

Zoom.

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A paper published in the New England Journal of Medicine floated an unproven theory about Covid: that mask wearing may be immunizing people. The idea is that masks may cut down on the number of viruses that a person breathes in, so the body’s able to mount an immune response instead of getting overwhelmed. 

It’s the same process that made variolation–the early form of inoculation against smallpox–work. A person was deliberately exposed to a small amount of the disease and the body probably mounted an immune response. Emphasis on probably. You couldn’t be sure who would become immune and who would get sick and quite possibly die. 

The mask theory rests on two unproven assumptions: that exposure to a lower dose results in a milder case and that mild or asymptomatic cases confer some immunity. More than that, the only way to directly prove it is through clinical trials that would expose people, some wearing masks and some not, to the coronavirus. Which is unethical. So at this point it’s basically an interesting thought.