Tag Archives: universal vaccine

No, vaccinated people do not shed spike proteins

Posted on by
69

The latest thing in nut theories–if it hasn’t been superseded by a newer one, and you’ll have to forgive me if I limp along behind this stuff–is that it’s dangerous for women who are still menstruating to even be around people who’ve been vaccinated.

Why’s that? So the little vaccy-things jump out of the vaccinated Person V and into still-fertile Person non-V, implanting some version of Rosemary’s baby that’s been updated to look like Bill Gates?

Quite possibly, with just the tiniest touch of exaggeration.

Utterly irrelevant photo: This is for all you British mystery fans out there. If you remember a detective called Campion, this is the flower he named himself after. It’s a wildflower–a.k.a. a weed–and grows wherever it damn well pleases. It stays in bloom for a good part of the year and is a cheery little beast. This is the red campion, in spite of being pink. It also comes in white.

The theory is that the vaccines shed the spike protein. (Please don’t ask about the mechanism for that.) Someone who described herself as a cosmic doula posted an Instagram video saying, “Women in their menstruating years are experiencing severe side effects from people around them having received this jab.” They miss their periods. They have excruciatingly painful periods. Post-menopausal women start to have periods. Cats flee from them.

Okay, I made up the bit about the cats, but you have to admit it’d be upsetting.

Someone on Facebook who likes to Capitalize stuff she Considers Important listed the side effects of being around a Vaccinated Person as bleeding, hemorrhaging, passing clots, irregular periods, miscarriages, severe cramps, abnormal pain, post-menopausal periods, and decidual casts.

Most of these things aren’t fun but they’re also not signals that an asteroid is headed for earth or that Bill Gates has implanted his own DNA into the Covid vaccines, which will turn us all into non-rich versions of him. They happen, even in non-pandemic times.

In other words, call me when men start having periods. You’ll have full attention. Until then, I’m not impressed.

Gynecologist Dr. Jennifer Gunter said, “Neither of the Pfizer or Moderna vaccines . . . nor the Johnson and Johnson vaccine . . . can possibly affect a person who has not been vaccinated, and this includes their menstruation, fertility, and pregnancy. Let me be very clear. The COVID-19 vaccines cannot affect anyone by proxy.”

So she’s no fun at all. And cats flee from her.

 

Vaccination and pregnancy

If we’ve had our fun now, and if the cats have crept back into the room, allow me to mention a study of 35,000 women that says the Moderna and Pfizer vaccines are safe for pregnant women–not to mention the people standing next to them. Their rates of complications, miscarriages, and premature births were the same as the rates for those things before the pandemic. 

The vaccines may also be safe for pregnant men, but it was hard to find a large enough pool for the researchers to follow. For the time being, guys, you’re on your own.

Longer-term follow-up is needed, but pregnant women face a higher risk of severe Covid and hospitalization than non-pregnant women in their age groups, although their babies don’t seem to be affected.  

The Johnson & Johnson vaccine was released too late to have been included in the study.

 

Yeah, but what are we immune to?

A new study says that the Covid vaccines activate–

Oh, hell, this is complicated, so you’re going to have to pay attention, okay?  The immune system has these cells that we’ll call helper T cells, although when they appear in court they’re known by their formal name, CD4+ T lymphocytes. And to distinguish themselves from the defendants, they wear those strange, lawyerly wigs that distinguish British barristers from the normal run of human beings. But never mind all that. We’re friends here and we can afford to be informal and wigless. Helper T cells it is.

The study says that once activated by either of the two mRNA vaccines (those are the Pfizer and the Moderna), the helper T cells will recognize any of the current Covid variants and slaughter the little bastards. 

Okay, that’s not a direct quote. I get carried away with the opportunity to slaughter small and bloodless things that have no apparent nervous systems so I can do it in good conscience. 

The activated helper T cells may also protect us against one of the coronaviruses that causes the  cold. 

Sorry, not all colds. Just one form.

This is important because our antibodies are cute little things but they’re not as smart as T cells and sometimes need a phone call to tell them where to go and what to do when they get there. 

But before we get too excited, first this was a small study and second it may only mean that they’re able to prevent the variants from causing severe illness, not to prevent all infections.  

 

The Pfizer upgrade

If all goes as expected, the Pfizer vaccine will soon be easier to ship. Up to now, it’s had to be kept at the temperature of dry ice, meaning a country needed one hell of an infrastructure to use it at all. In its new form, an ordinary freezer will keep it safe. 

It’s also one of the more expensive vaccines on the market, so making it easier to ship won’t solve all the problems involved in getting it where it’s most needed.

How’s it stacking up against the variants?

Pfizer’s CEO, Albert Bourla, said “We have already data for the UK [variant]—I hate using the countries, but people know them like that—which is very prominent in Israel… efficiency was 97 percent.

“We have data from South Africa, with the South African variant, and overall the efficacy was 100 percent. And also have data from Brazil. And it looks also this is very well controlled.”

You’ll notice that he didn’t give us any numbers from Brazil. Let’s assume there’s room for improvement.

It takes, he said, 100 days to tweak a vaccine so that it’s more effective against a worrying variant. 

 

The search for a universal vaccine

So will there ever be a Covid vaccine that doesn’t need tweaking? 

Possibly, and I suspect I’ve written about it before but it’s not as if I pay attention to what’s going on here. That’s your job.

One has shown encouraging results in animal studies. It targets a part of the virus that seems stable–in other words, it doesn’t mutate–and indications are that it will protect against multiple coronaviruses, not just Covid. So it could–potentially, remember; we’re not there yet–protect against coronaviruses that have yet to make their way into our lives, and also against multiple cold viruses.

And it can be produced cheaply. If you brewed it in a keg the size of your car’s gas tank (or petrol tank if you’re speaking British), it would cost $1 a dose. That’s compared to $10 a dose for the mRNA vaccines like Pfizer. 

But if production is ramped up, you won’t be brewing it in your car’s gas tank, or even (Prohibition-style if you know your US history) in your bathtub. You’ll be using industrial-scale tanks and it’ll be a whole lot cheaper. 

“If you have two or three or four, pretty soon you get enough vaccine to immunize everybody in the world,” according to Dr. Steven Zeichner of the University of Virginia, in Charlottesville.

The vaccine’s designed to attack a part of the Covid virus called viral fusion peptide, which sounds like it’s going to blow something up but is just another damn peptide, not a nuclear weapon.

When in your life did you hear the word peptide as much as you have this past year? 

This particular peptide is a universal coronavirus part. That means you can get from any used parts dealer, any junkyard. Etsy has it. I’d mention Amazon but I’m carrying on a one-person boycott so I won’t. It’s a part of the spike protein that hasn’t shown any changes so far and that’s unlikely to show any in the future. It’s like the headlight that’s used on this year’s model and also the 1957 model. 

Or so Zeichner says, and he knows more about this than I do–which wouldn’t be hard. Let’s say he knows considerably more than I do and trust his judgement on this. After all, he did have enough sense not to bring junkyards or headlights into the discussion. I’m to blame for that.

Even if he turns out to be wrong and under pressure from the vaccine the peptide does mutate, we will have been given some breathing room.

This doesn’t have to be a new vaccine. Existing vaccines will be able to incorporate the target as they add new tweaks.

But a universal vaccine isn’t ready for human studies yet. For one thing, in animal tests it prevented severe symptoms but not infection. The developers want to tinker, retune the engine, give it a new set of tires, do all those things that will make it more lethal to coronaviruses. The preliminary data, they say, are exciting, but these are the very early stages still.

Is a universal coronavirus vaccine a pipe dream?

Posted on by
33

Scientists are in the (very) early stages of working out a universal vaccine against coronaviruses–one that would block not only Covid’s existing and future variants but any new coronaviruses that emerge.

Okay, let’s call that a possible vaccine. It could easily not work out, but on the other hand no law of nature says that it can’t. Scientists have been doing the next-to-impossible a lot lately. I’ve started to take it for granted. 

IMG_0082 (1)

Irrelevant photo: A camellia bud, stolen from an old post because I’m trapped in WordPress’s horrible new editing program and haven’t found a way to drop in new photos at full size. I had a way to avoid the new system, but they’ve blocked it.  

They can approach the task in two ways. One is to make a mosaic vaccine. That has nothing to do with Moses–you know, the guy with the stone tablets. It’s from the word for those tiny pieces of colored tile that make up a picture. The vaccine takes particles from several Covid variants or other coronaviruses and sticks them onto a nanoparticle–a very tiny biological structure made up of proteins. Think of it as sticking some olives on a toothpick.

Or don’t. It’s your mind. I’ll never know. But if you do want to go out on that imaginary limb with me, watch while I saw it off behind us: We’re going to take that toothpick with its olives and drop it into the martini of your immune system.

Thwack. That was the sound of us hitting the ground, olives and all.

It would make a nice lullabye, don’t you think?

Now that we’ve dusted ourselves off, we can let our immune systems figure out what those bits of virus have in common and arm itself–and us–against that.

When this was tried in mice, their immune systems created a broad range of neutralizing antibodies. And creating neutralizing antibodies is the main goal of any vaccine.

Mice–as no doubt you already know–are not humans. They’re also not martinis, so this may not transfer seamlessly from them to us. But it holds some promise.

If you’ll let me brush those twigs out of your hair, we can go on.

The second approach has the scientists looking for features that are common to all coronaviruses. That could mean analyzing their genetic sequences to see where they overlap. It could also mean looking for immune cells that react to either all coronaviruses or to a number of variants, and then mapping the parts of the virus that they target. After that, all that’s left is to create a vaccine aimed at that spot.

Nothing to it.

Those of you who don’t drink will be relieved to know that no martinis are involved in this approach.

Now I’ll throw cold water on the whole project and tell you that scientists have been trying to come up with a universal flu vaccine and a universal HIV vaccine for years. The candidates have been safe but not impressively effective. Still, Covid doesn’t mutate as quickly as either HIV or the flu.

Yes, really. In spite of everything we’ve been reading about variants. This is what’s called slow mutation. 

So no one’s offering guarantees that this will work, but it’s a bright spot on the horizon. 

The horizon, unfortunately, is a good long way away.

Policy-type stuff

An international survey of how countries handled the pandemic shows that autocracies and democracies did equally well and equally badly, as did rich countries and poor countries and countries governed by populists and countries governed by technocrats. In other words, none of those were decisive factors.

Lockdowns of one sort or another do break the chain of infection, but they’re not universally successful. If the population doesn’t trust the government, they don’t seem to work. (I’m stretching the study’s conclusion a bit there. It sounds more tentative about it.) Economic support may make lockdowns more effective. (“May”? I can’t imagine the part of the world where making sure people who can’t work can still eat and pay their rent wouldn’t help. Never mind. It’s not my study. They’re not my conclusions.)

Some countries with strong scientific capacity and healthcare systems have responded badly, and some countries with far less (Mongolia, Thailand, Senegal) have both kept their people healthy and the economy running. 

Some countries (Taiwan, Vietnam, and New Zealand get a mention) did well in controlling the first wave and kept control from there on. Others did well in the first wave but the waves that followed swept over them. 

I’ll get out of the way now and let the people involved in the study have the last word:

“While our work has tracked individual governments’ responses, it is clear that exiting the pandemic will require global cooperation. Until transmission is curtailed throughout the world with restrictions and vaccinations, the risk of new variants sending us back to square one cannot be ignored.”

In other words, we’re all in this together. Even when we don’t act as if we are.

*

So let’s check in on a country that’s managed well and hasn’t gotten a lot of publicity. 

Before it had its first Covid case, Iceland had a testing system and a contact-tracing team, ready to go to work as soon as they found their first case. They put everyone who tested positive into isolation and traced their contacts. The word one of the people involved uses, with no apology, is aggressively.

Isolation–as least in Reykjavik–is in a hotel that was converted for the purpose. In response to which the staff walked out. The man in charge (I have no idea what his title is–sorry; let’s call him Gylfi Thor Thorsteinsson, since that’s his name) coaxed them back. They work in full protective gear. Thorsteinsson at least goes into people’s rooms to keep them company.  I assume many of the others go in as well, but the article I read didn’t say. In the past year, the hotel’s taken care of more patients than all the hospitals in Iceland rolled into one.

After Iceland got its first wave under control, they closed the hotel. Then they immediately had to reopen it when two tourists who’d tested positive went a-wandering. And by immediately, I do mean immediately. They just had a goodbye party for the staff when they had to say hello again. 

Now anyone who lands at the airport is tested and put into quarantine. As a result, Iceland is a country where people can go to bars, eat out, and generally wander the world without masks, as if life was normal. Not because they’re risking their lives and other people’s but because it’s safe.

At one point, someone carrying the UK Covid variant slipped through the net and spread it to a second person, who went to work in a hospital and in case that wasn’t bad enough went to a concert with 800 other people, who all crammed into the bar during the intermission. 

Whee. Viral playtime.

Within hours, the tracing system had contacted every one of them. Within days, they’d tested 1,000 people, finding two cases, and they were taken to the isolation hotel. 

And that was it. The virus was contained. 

Why has Iceland been so successful? Thorsteinsson said it’s because “it has been the scientists making up the rules, not the politicians. That matters. They know what they are talking about, the politicians do not.”

The prime minister, Katrin Jakobsdottir, seconded that. 

“I think it’s important for a politician to realize what is politics and what needs to be solved by scientific means. It’s my firm belief that we need to listen more to the experts.”

 

A short technical rant

WordPress in its wisdom has blocked the back road that once allowed me to use its manageable Classic Editor, so I’m now trapped in the new one. If anyone knows how to size photos (or knows a back road), pleasepleaseplease let me know. Thanks.