Does lockdown damage the economy? 

If British lockdown is a song, the chorus is a sour political sound that comes from throwback Members of Parliament calling for lockdown’s end. Let’s look at lockdown and the impact it has on an economy, since that’s one of the primary arguments against it. 

 

The costs of lockdown

Those wild-eyed radicals at the International Monetary Fund looked at the changes in travel, electricity use, and unemployment claims and say the economy deteriorated before government restrictions came into force and also began to recover before they were lifted. Voluntary social distancing and lockdowns, they say, had almost exactly the same impact. In other words, the problem is the pandemic, not the lockdowns.

A different study compared Demark and Sweden and reports almost the same drop in consumer spending during the first wave of the pandemic, although Denmark locked down and Sweden didn’t. Again, they’re saying the economic damage came from the pandemic, not the lockdown.

We could go on, getting into quality-adjusted life years (QALYs), which are a particularly grisly measurement the National Health Service uses (and for all I know, so do health insurance companies or other countries’ health services) to decide if a medicine or treatment is a good buy–or at least an affordable one. It weighs additional length of life against quality of life against money. Because money’s the ultimate measure of everything in our economy, folks. Even our lives.

Irrelevant photo: Crocuses coming up in spite of our recent cold snap.

But I’ll leave you at the door of QALYs while I go home and have a nice cup of tea all by myself. Or with you if you show up and the pandemic’s over. The calculations involved are enough to scare me off. What I can tell you is that the article I’m linking to claims that the lockdown opponents are using QALYs wrong when they cite them to prove their point. 

I’d probably use them wrong too, and prove no point at all. Hence the tea. 

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Speaking of money and Covid, landlords in England can’t evict tenants who fall behind in their rent because of the pandemic, but that only holds till the end of March. After that, anything could happen. The ban could be extended. The ban could be allowed to lapse. Spaceships could land and magically implant some good sense into all of us.

I like the third possibility myself, but I admit it’s not the most likely.

Some 450,000 families are behind on their rent because of the pandemic. If you want your hair to turn as gray as mine, you can add in the number of families who’ve fallen behind on their mortgage payments. They can’t be evicted yet either, but they’re facing the same three possibilities. 

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Reopening the schools or keeping them closed is an alternative chorus of the lockdown song.

A study looking at Sweden, with it no-lockdown approach to the pandemic, reports that keeping the schools open with only minimal precautions meant the teachers faced a doubled risk of catching Covid. And their partner had a 29% higher risk. 

The point of comparison was teachers who shifted to teaching online.

The kids’ parents had a 17% higher risk. Not enough kids were tested for them to register in the study.

 

Variant news

Scientists have found some new Covid variants. One popped up in southern California. It was found in October and it’s spread around the country and into other countries, including Australia and New Zealand, where we can assume it’s been stomped out thoroughly.

It’s not clear yet if it behaves any differently from the same-old, same-old variants, but it carries a change on the spike protein, which may or may not turn out to be important. 

The spike protein? It’s the key that lets the virus into human cells. The fear is that a change there may mean the virus gets better at breaking in or at evading our immune systems–or our vaccines. 

Another new Covid variant’s been found in Britain, in Denmark, in the U.S., in Australia, and in some other countries. So we don’t get to wave the flag over this one. It also has some changes to the spike protein, but it’s too early to know how significant the changes are. 

Some experts are recommending surge testing to try to stomp the beast out. Other experts are saying, “Yes, you idiots, but until you offer financial support to people who test positive, a lot of people will hide out instead of getting tested because they can’t afford to take two weeks off work. Or ten days. Or three minutes.”

That’s probably not an exact quote, but it is a good point.

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Recent newspaper articles gave people a good scare by saying that British variant–also called the Kent variant; one of our world-beating contributions to the pandemic–is linked to a higher death rate. But that’s the same as saying it causes more deaths. It’s one of those read-the-fine-print things. 

A variant being linked to a higher death rate means it may be the cause but it may just happen to be in the room when the higher death rate happens. It hangs out with a rough crowd and they’re happy to let it take the blame. The variant has spread through nursing homes, which are full of people who are particularly vulnerable. The virus wouldn’t have to be supercharged to do a lot of damage among them.

But it’s also possible–not proven, but possible–that people infected with it have higher viral loads, which could both make it more contagious and harder to treat. But even that last part, about a higher viral load making it more contagious and harder to treat, is speculation.

It’s not time to panic over this one–we’ll have all the time we need to do that later if we have to. 

The non-speculative good news is that the current vaccines do a good job of targeting the variant. 

 

A quarantine update

If England’s rules on quarantine hotels looked absurd over the weekend, with its insistence on mixing people from Group A with people from Group B and then treating only Group A as scary enough to quarantine–

We’ll start that over, okay? If they looked absurd over the weekend, Scotland’s looks almost as silly today. Scotland, we read at first, was going to have everyone do a hotel quarantine: Group A right along with Group B. Now it turns out there’s a loophole. A father and daughter who flew from the U.S. by way of Ireland can quarantine at home. Because they came through Ireland. 

I’m happy for them. The child’s eight and hasn’t seen her mother in sixteen months. But it makes no sense at all. 

 

A bit of good news

Okay, I admit that this isn’t going to give us anything immediate, but long term it could help. An antiviral called EIDD-2801 (they haven’t passed that one through a focus group yet) may fight Covid in several ways: In the lab, it keeps Covid from replicating and from infecting human cells. In a mouse trial, two days of treatment reduced virus replication 25,000-fold when they gave it two days after exposure and 100,000-fold when they gave it twelve hours before and after exposure. 

They’ll be going into phase 2 and 3 trials in humans to test its safety and effectiveness in Covid patients.

How Covid mutates and why that might be a good thing

There’s good and bad news about the way Covid mutates, and it’s all wrapped around the same bit of information. 

Like most non-experts, I use the word mutate loosely. If something genomeish leads to change, I think it’s a mutation. Which goes to show you what I know.

Covid, it turns out, doesn’t just mutate, it also recombines, meaning it mixes large chunks of its genome, not just single genes. If a mutation’s a typo, recombination is a cut-and-paste error, dumping a largish chunk of text in the wrong place. And while the virus proofreads typos fairly well, it doesn’t catch cut-and-paste problems as effectively.

I’ve had that problem myself. I still wince at something quite horrible that I let go into print because the spelling was right and my eye didn’t pick up the change in meaning. And I’m larger and (I like to think) more complicated than a virus.

Most of those recombination errors, like most mutations, make a mess and that particular virus doesn’t get to leave little virette progeny behind. But some of them work and the virus changes.

Irrelevant photo: One of Janey’s crocuses.

Is recombination what’s happening with Covid? Possibly. The Kent variant has more than a dozen mutations and they seemed to appear all at once. Emphasis on seemed. A lot of what goes on happens in the kitchen while we’re out front cleaning the dining room. Feng Gao, a virologist from China, says we don’t yet have proof of recombination. “Diversity, no matter how much, does not mean recombination. It can well be caused by huge diversification during viral evolution.”

So let’s not get carried away with this. We’re dancing at the edges of what’s known. But (damn, that tune’s catchy, so I’ll do a few more steps) recombination may be how viruses that infect one species jump to another species: by swapping a bit of genetic code .

It’s possible that recombination means a more dangerous virus will appear–either a new one or a more dangerous form of Covid. So there’s our bad news. 

But the good news is that experiments with a mouse coronavirus show that blocking a single enzyme keeps the virus from correcting its typing errors and recombination events happen much less often. If this holds for Covid, the right drug might be able to block recombination and (or maybe that should be or) push the virus to mutate so badly that it ends up in something called error catastrophe–basically, the evolutionary equivalent of falling off a cliff. While dancing to that catchy little tune.

As a way to treat Covid, blocking the enzyme could make antiviral drugs more effective.

The enzyme goes by the name of nsp14-ExoN, which isn’t particularly catchy. If we’re going to be spending time with it, it needs a nickname. But whatever we call it, it’s common in coronaviruses, so if this works it opens up the possibility of curing other coronavirus diseases as well. 

 

Covid variants

If Britain didn’t end up with the world-beating test and trace system Boris Johnson promised us–and believe me, it didn’t–it may have come up with a world-beating strain of Covid instead: the Kent variant; the variant I mentioned that has all those mutations. Sharon Peacock, the director of the Covid-19 Genomics UK consortium tells us it looks likely to sweep the world.

And unlike the test and trace system, we didn’t pay a penny for it.

Go Britain!

The consortium is testing the genomes on a randomly selected 5% to 10% of all positive Covid samples in the country but aims to test them all in order to keep track of how the virus is mutating.

And speaking of variants, the World Health Organization says the small trial that found the AstraZeneca vaccine to be largely ineffective against the South African variant was inconclusive. They’re not saying the vaccine’s definitely effective against it, only that it isn’t definitely ineffective. 

Which is better than nothing. 

 

Covid and Coca Cola

How much space would all the Covid viruses in the world take up if they could be packed neatly for shipping? They’d fill a Coke can

They’d also fill a can of supermarket brand fizzy orange-flavored sugar water, but Covid’s a brand-name kind of virus. Coke it is. So in the scene where someone yells, “Don’t open the can!” for pete’s sake, don’t open the can. You know what happened when Pandora didn’t listen to the warnings?

I’m not telling. But I did give you a link.

 

Spreading the virus

More than half of all Covid cases are spread by people who have no symptoms. They may be less infectious than people who are sick, but they could well make up 80% of the total number of people carrying the disease. And they’re wandering through the world shedding viruses, not lying in bed at home.

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A study by the U.S. Centers for Disease Control found that wearing two masks can reduce the chance of getting Covid by 90% or more. Yes, not just transmitting but catching the damned thing. 

The study had its limits. It tested a tight-fitting cloth mask over a surgical mask, not two surgical masks and not two cloth ones, and it only looked at one type of cloth masks, although the world’s awash with different types just now. And as the article where I first read this put it, it also didn’t consider “men with beards or children.”

Does having children interfere with the fit of men’s masks more than women’s? Hard to say. The study didn’t test that. 

To keep everything in perspective, an engineering professor says that the only reason to wear two masks is to get a better fit. But the masks most of us wear do fit loosely, so double masking might be worthwhile, no matter who’s right.  

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Two weeks after U.S. states introduced mask mandates (they haven’t all), the weekly growth in hospitalization rates dropped by 2.9% among people who are 40 to 64. After three weeks it dropped 5.5% among people 18 to 64.

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Every so often, you’ll find someone saying that Covid’s no more dangerous than a bad outbreak of the flu. So do we have any figures on how much more dangerous it is? 

Yup, some. The risk of death is 3.5 times higher. That number comes from comparing people who are hospitalized with the Covid against those hospitalized with flu. It ignores whatever long- term effects Covid has on the unhospitalized, so I’d say it’s undercounting. Still, it’s a number, and numbers help. 

At least they help most people. 

Covid patients also had one and a half times greater use of the intensive care unit and one and a half times longer hospital stays. And they were more likely to need a ventilator.

In case you think Covid’s only a problem for the old and the ill, not many of the hospitalized Covid patients had other illnesses and 21% were younger than 50. People under 50 made up 24% of the intensive care admissions.

As far as I can see, that doesn’t address the problem of how easily Covid spreads compared to flu. It only compares hospitalized patients.

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Worldwide, the number of reported Covid cases is down for the fourth week in a row. Take a deep breath. The drop is uneven, it doesn’t count unreported cases, and we forgot to get a guarantee that it won’t go back up, but we have to take our good news where we can get it. This is good news.

 

Is there any news on curing the thing?

In a small study, a common asthma treatment, budesonide, cut the need for hospitalization and urgent care by 90%, and people who took it within seven days of showing symptoms recovered more quickly than the control group. Better yet, it cut the number of people with symptoms that lingered after twenty-eight days. 

As usual, it was a small study–146 people–so it’s preliminary, but budesonide is a well-known and well-studied drug, which would speed the process if it’s adopted.

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The U.S. Food and Drug Administration has approved a combination of two monoclonal antibodies that can keep high-risk patients from developing Covid that’s severe enough to hospitalize them. A similar drug had already been approved. Both take Covid antibodies and synthesize them so they can be given to patients as a drip. 

And it’s that drip business that’s causing trouble. Initially, getting them from vial (or whatever they come in) into human took an hour. It can now be done in sixteen minutes. But some hospitals have been so overwhelmed they haven’t had time to deal with it. 

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A team of researchers in China has identified six drugs that the FDA has already approved for other uses that could be repurposed to treat Covid. They whittled that down from 3,769. They still need to be tested in the real world, but already having FDA approval for other purposes means that if they work they could be put to use quickly.

After that, the article went over my head, but it has to do with proteases and substrates, not to mention clades. Have fun.

 

Your feelgood story

New York software developer Huge Ma tried to make his mother a Covid vaccination appointment and discovered that not only did the city and state have different systems that weren’t talking to each other but that there were dozens of separate websites, each one demanding that you sign up a different way.

So he took a couple of weeks and made a free website, TurboVax, that compiles information from the three main city and state sites and sends information on available appointments to Twitter.

It cost him $50 to make.

The difficulty of booking an appointment is one reason–although far from the only one–that vaccines are going disproportionately to white New Yorkers. 

“It’s sort of become a challenge to myself, to prove what one person with time and a little motivation can do,” he said. “This wasn’t a priority for governments, which was unfortunate. But everyone has a role to play in the pandemic, and I’m just doing the very little that I can to make it a little bit easier.”